Through Vial Impedance Spectroscopy (TVIS): A new method for the development of manufacturing processes for inject-able drug products.10th International Workshop on Impedance Spectroscopy; 2017 Sept 28-29; Chemnitz, Germany.

cite as:

Smith, G. (2017) Through Vial Impedance Spectroscopy (TVIS):A new method for the development of manufacturing processes for inject-able drug products. Podium presentation at 10th International Workshop on Impedance Spectroscopy; Sept 28-29; Chemnitz, Germany.

- Introduction to TVIS (i) equations for the derivation of complex capacitance from the measured impedance, (ii) a simplified equivalent circuit model for the observed relaxation process; (iii) example impedance spectra and the equivalent capacitance spectra for the TVIS vial with a 5% w/v solution of lactose in the liquid and frozen states and empty

- Applications for TVIS (i) calibration of TVIS parameter F_PEAK for the temperature of the ice and the subsequent application of the derived parameter T(F_PEAK) in the prediction of the temperature of ice during the primary drying stages; (ii) use of temperature compensated value for the height of the dielectric loss peak (C_PEAK) for the determination of the ice sublimation rate.