Smith G. (2016) Podium presentation at PDA Europe Pharmaceuitcal Freeze Drying Technology; 2016 Sept 27-28; Strasbourg, France.pdf (2.05 MB)

The Application of Through Vial Impedance Spectroscopy (TVIS) for Process Parameter Determination in Freeze Drying Method Development. PDA Europe Pharmaceutical Freeze Drying Technology; Sept 27-28; Strasbourg, France

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posted on 29.04.2020 by Geoff Smith
cite as:
Smith G. (2016) The Application of Through Vial Impedance Spectroscopy (TVIS) for Process Parameter Determination in Freeze Drying Method Development. Podium presentation at PDA Europe Pharmaceutical Freeze Drying Technology; 2016 Sept 27-28, Strasbourg, France

The presentation starts with a description of the through vial impedance spectroscopy (TVIS) and the measurement system before going on to describe applications in the determination of various process parameters and related phenomena:
 Vial heat transfer coefficient (KV)
 Dry layer resistance (RP)
 Ice nucleation (onset of ice growth)
 Glass transition
 Eutectic crystallization
 Collapse


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