Application of a novel impedance-based freeze-drying Microscopy for formulation development. Formulation solutions for diversifying biopharmaceutical portfolios, 11th July 2019, Manchester, UK

posted on 12.02.2020 by Anand Vadesa, Geoff Smith, Neill Horley, Paul Dalby, Kevin Ward

Poster and Podium presentation at Formulation solutions for diversifying biopharmaceutical portfolios; Knowledge Transfer Event (Innovate UK) at Manchester Institution of Biotechnology; 11 July 2019.

Over the past few decades, a number of analytical instruments have been developed for the characterization of product formulations intended for Lyophilisation. Freeze-drying microscopy (FDM) is now used routinely to determine the critical temperature at which the product may collapse during primary drying (Tc) whereas a combination of differential thermal analysis (DTA) with electrical impedance analysis has been used to study the critical temperatures of a sample in a frozen state (i.e. the glass transition, ice crystallisation and eutectic melting temperatures). In this study, a combination of impedance spectroscopy with freeze-drying microscopy (Z-FDM, G. Smith, 2019) has been reported for the first time.


Innovate UK - FastLyo Project (grant ref: 133425)